13 Common Symptoms of Growth Hormone Deficiency

 

Growth hormone (GH) is a peptide hormone that stimulates growth, cell reproduction, and protein synthesis. GH is produced by the anterior pituitary gland, located in the brain. It is released into the bloodstream, which travels to other body parts. GH promotes growth in children and adolescents and helps maintain bone, tissues, and organs in adults.

What Benefits of Growth Hormone?

Growth hormone has a range of benefits. In children and adolescents, GH helps spur growth in height. In adults, GH helps maintain muscle mass, tissues and organs, bone density, and metabolism. GH also plays a role in wound healing and recovery from injury or illness.

1. Increased Muscle Mass

One of the primary benefits of growth hormone is that it can help to increase muscle mass. Human growth hormone is responsible for the growth and development of the human body and helps promote the growth of skeletal muscle tissue. A study published in the Journal of Clinical Endocrinology and Metabolism found that men injected with human growth hormone gained an average of four pounds of muscle mass over six weeks.

2. Decreased Body Fat

In addition to increasing muscle mass, growth hormone can help decrease body fat. Human growth hormone helps to regulate metabolism, and it has been shown to promote the breakdown of stored body fat. A study published in the Journal of Clinical Endocrinology and Metabolism found that men injected with human growth hormone lost an average of four pounds of body fat over six weeks.

3. Improved Bone Density

Another benefit of human growth hormone is that it can help to improve bone density. Human growth hormone helps to stimulate the production of new bone cells, which can help to improve overall bone health. A study published in the Journal of Clinical Endocrinology and Metabolism found that men injected with human growth hormone increased bone density after six weeks.

4. Enhanced Exercise Performance

Growth hormone can also help to enhance exercise performance by increasing muscular strength and endurance. A study published in the Journal of Applied Physiology found that men injected with human growth hormone increased their bench press max by 34% after six weeks. Additionally, a study published in the European Journal of Applied Physiology found that men injected with human growth hormone increased their VO2 max (a measure of aerobic fitness) by 16% after eight weeks.

5. Improved Recovery from Exercise

In addition to enhancing exercise performance, human growth hormone can also help to improve recovery from exercise. Growth hormone helps to promote the repair and regeneration of skeletal muscle tissue, which can help athletes recover from strenuous exercise more quickly. A study published in the Journal of Applied Physiology found that men injected with human growth hormone reduced their recovery time from exercise by 23%.

6. Improved Heart Health

Human growth hormone can also help to improve heart health by reducing LDL cholesterol (the “bad” cholesterol) and increasing HDL cholesterol (the “good” cholesterol). Additionally, human growth hormone has been shown to reduce blood pressure and improve blood sugar control in people with diabetes. All of these effects can help to reduce the risk of heart disease.

7. Improved Brain Function

Human growth hormone has also improved brain function by increasing cognitive performance and memory recall. Additionally, human growth hormone has been shown to protect against age-related cognitive declines, such as Alzheimer’s disease and dementia. A study published in the journal Neurology found that people with Alzheimer’s disease treated with human growth hormone had improved cognitive function after six months.

8. Healthier Skin

Growth hormone can also lead to healthier skin by improving collagen production and reducing wrinkles. Additionally, growth hormone has been shown to improve wound healing and reduce the appearance of scars.

9. Stronger Immune System

Another benefit of growth hormone is that it can help to strengthen the immune system. This is especially beneficial for people who are susceptible to infections or illnesses. Growth hormone has also been shown to reduce inflammation, benefiting people with autoimmune disorders.

10. Lower Risk of Cancer

Growth hormone has also been linked with a lower risk of cancer, as it helps to suppress tumor growth and metastasis. Additionally, growth hormone has been shown to improve the efficacy of cancer treatments such as chemotherapy and radiation therapy

What is Growth Hormone Deficiency?

Growth hormone deficiency (GHD) occurs when the body does not produce enough growth hormone. GHD can occur at any age, but it is most common in children and adolescents. GHD can lead to short stature, delayed puberty, and other problems.

What Causes Growth Hormone Deficiency?

GHD can be caused by a number of factors, including:

– Pituitary tumor: A tumor on the pituitary gland can interfere with GH production. This is the most common cause of GHD in children.

– Trauma: Head injuries or surgery on the brain or pituitary gland can damage the cells that produce GH.

– Infection: Viral infections, such as meningitis or encephalitis, can damage the cells that produce GH.

– Congenital abnormalities: Abnormalities present at birth, such as Turner syndrome or Prader-Willi syndrome, can cause GHD.

-Radiation therapy

What are the Symptoms of Growth Hormone Deficiency?

The symptoms of GHD vary depending on the age of the individual.

In children, GHD can cause:Growth hormone deficiency in children can be difficult to spot since it often develops gradually and the signs can be subtle. Common symptoms of this deficiency include delayed development in terms of height and weight, unclear facial features, a decrease in strength and physical performance, difficulty maintaining muscle mass, and fat accumulations around the midsection. Other less frequently observed signs may include changes in mood, poor concentration, feeling fatigued and weak. Although these symptoms can sometimes be indicative of other issues as well as growth hormone deficiency, it is essential to bring any concerns or questions to your child’s doctor for a diagnosis.

 

6 Symptoms of growth hormone deficiency in children:

-Slow Delayed growth: Children with GHD tend to be smaller than their peers. They may also have a slower growth rate, delayed puberty, and poor muscle development.

-Short stature

-Delayed puberty:Delayed puberty: Girls with GHD may have delayed onset of puberty, while boys may have delayed pubertal changes, such as voice deepening and increased muscle mass.

-Fatigue

-Attention Deficient

-Mood Swings

In adults, GHD can cause:

Growth hormone deficiency in adults can have serious effects on the body. Common signs and symptoms of GH deficiency in adults include weight gain, trouble sleeping (insomnia), fatigue, weakened bones (osteoporosis), loss of muscle mass and strength, a decrease in bone density, higher risk of cardiovascular disease, hair loss all over the body, increased triglyceride levels in the blood, slow wound healing and an impaired metabolism. Left untreated or unmanaged, growth hormone deficiency can cause both physical and mental health issues for years to come. It is important to recognize the signs and symptoms early so as to seek prompt treatment from a medical professional before irreversible damage is done.

13 Symptoms of Growth Hormone Deficiency in Adults

– Fatigue: Adults with GHD may feel tired and have decreased energy levels.

-Decreased muscle mass

-Thinning hair

– Muscle loss: Adults with GHD may experience muscle loss

– Weakness: Adults with GHD may feel weak and have difficulty exercising.

– Bone loss: Adults with GHD may be at risk for osteoporosis, bone thinning, or reduced bone density.

– Increased body fat: Adults with GHD may have increased body fat, particularly around the waist. They may also have trouble losing weight.

– Depression and Anxiety: Adults with GHD may suffer from depression and anxiety.

-Erectile dysfunction

-Decreased libido

-Sleep problems

-Premature skin aging

-Cardiovascular disease

How is Growth Hormone Deficiency Diagnosed?

Growth hormone deficiency is diagnosed through medical history, physical examination, and laboratory testing.

Medical history: A doctor will take a medical history and ask about symptoms. The doctor will also ask about any family history of GHD or other pituitary disorders.

Physical examination: A physical examination can help the doctor assess height, weight, body composition, and pubertal development.

Laboratory testing: A low GH level is indicative of GHD. A blood test can measure GH levels in the body. The test is usually done in the morning when GH levels are highest. A doctor may order a GH blood test if a child has symptoms of GHD, such as slow growth or short stature. An adult with symptoms of GHD, such as fatigue or decreased muscle mass, may also have a GH blood test.

Other blood tests can measure levels of IGF-1, a hormone produced in response to GH. The IGF-1 blood test measures levels of insulin-like growth factor 1 (IGF-1). IGF-1 is a protein that promotes growth. GH regulates the production of IGF-1. Low levels of IGF-1 less than 100 may be a sign of GHD.

Imaging studies: Imaging studies, such as MRI or CT scans, can be used to assess the size and location of a pituitary tumor if present.

What are the Treatment Options for Growth Hormone Deficiency?

The treatment for growth hormone deficiency depends on the cause. If a pituitary tumor causes GHD, surgery may be necessary to remove the tumor. If GHD is caused by head injury or surgery, GH replacement therapy may be recommended. GH replacement therapy involves injections of GH into the muscles or under the skin. GH replacement therapy can help children and adults with GHD achieve normal growth and development. It can also help adults with GHD maintain muscle mass, bone density, and metabolism.

Types of prescription growth hormone?

The FDA has approved several types of synthetic GH or recombinant human GH for use in the United States. It is a man-made form of GH that is identical to the natural growth hormone produced by the body. Genotropin is available in an injectable form and is prescribed to children and adults with growth hormone deficiency. Synthetic GH helps these individuals achieve normal growth and development, and it can also help adults maintain muscle mass, bone density, and metabolism.

These include:

  • Genotropin
  • Humatrope
  • Norditropin
  • Omnitrope
  • Serostim
  • Zorbtive

How are synthetic growth hormone medications administered?

Synthetic growth hormone medications are administered through injection, either into the muscles or under the skin. The injections are usually given daily, and the dosage will be determined by a doctor based on the individual’s needs.

What are some alternatives to synthetic growth hormone medications?

GH Secretagogues

GH secretagogues are peptides or non-peptide agents that stimulate growth hormone release from the pituitary. They include GHRH and its analogs, ghrelin analogs (known as GH-releasing peptides) or GHS (GH secretagogue), and amino acids (e.g., arginine or ornithine). Secretagogues act on the pituitary gland, binds to growth hormone receptors, or mimic the natural release of growth hormone from the pituitary gland.

GH secretagogues have short-lived effects and provide a relatively weak boost in GH exposure compared with GH synthetic medications.

These medications are used to treat adults with growth hormone deficiency. They are not approved for use in children. Secretagogues are available as pills, injections, or nasal sprays. The dosage and type of secretagogue will be determined by a doctor based on the individual’s needs.

What are examples of secretagogues?

Some common examples of secretagogues include:

Pituitary Secretagogues:

-Ghrelin is a hormone produced in the stomach and stimulates the release of growth hormone from the pituitary gland. Ghrelin levels increase before meals and decrease after meals. This hormone may play a role in weight gain and obesity.

-Sermorelin is a growth hormone secretagogue available as a pill, injection, or nasal spray. It works by stimulating the release of growth hormone from the pituitary gland. This increases the amount of growth hormone in the blood and helps to improve symptoms of growth hormone deficiency. Sermorelin is used to treat adults with growth hormone deficiency. Sermorelin is not approved for use in children. The dosage and type of sermorelin will be determined by a doctor based on the individual’s needs.

GH receptor agonists:

GH agonists are medications that bind to a receptor and activate the receptor to produce a response. There are specific agonists for different types of growth hormone receptors. These agonists can be used to treat adults with growth hormone deficiency. They are not approved for use in children. Agonists are available as pills, injections, or nasal sprays. The dosage and type of agonist will be determined by a doctor based on the individual’s needs.

Some common examples of growth hormone agonists include:

-Pegvisomant (Somavert) is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Pegvisomant is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Pegvisomant helps these individuals achieve normal growth and development.

-Nampt (Ventavis) is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Nampt is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Nampt helps these individuals achieve normal growth and development.

Tev-tropin is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Tev-tropin is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Tev-tropin helps these individuals achieve normal growth and development.

Growth hormone-releasing hormone analogs

A GHRH analog is a medication that stimulates the release of growth hormone. It works by mimicking the release of growth hormone by the pituitary gland. This increases the amount of growth hormone in the blood and helps to improve symptoms of growth hormone deficiency.

These medications are used to treat adults with growth hormone deficiency. They are not approved for use in children. GHRH analogs are available as pills, injections, or nasal sprays. The dosage and type of GHRH analog will be determined by a doctor based on the individual’s needs.

Some common examples of GHRH analogs include:

-Nesiritide (Serostim) is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Nesiritide is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Nesiritide helps these individuals achieve normal growth and development.

-CJC-1295 is a man-made growth hormone identical to the natural growth hormone produced by the body. It is a peptide, which means it is composed of amino acids. CJC-1295 is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. CJC-1295 helps these individuals achieve normal growth and development.

-Ipamorelin is a man-made growth hormone identical to the natural growth hormone produced by the body. It is a peptide, which means it is composed of amino acids. Ipamorelin is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Ipamorelin helps these individuals achieve normal growth and development.

-Oxytocin is a hormone that is produced in the body. It is sometimes called the “cuddle hormone” because it is released when people hug or sit close to each other. Oxytocin is also a GHRH analog, meaning it stimulates growth hormone release. Oxytocin is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Oxytocin helps these individuals achieve normal growth and development.

-Tesamorelin (Egrifta) is a man-made growth hormone identical to the natural growth hormone produced by the body. It is a peptide, which means it is composed of amino acids. Tesamorelin is currently the most effective HGH secretagogue in the market. It has been proven to increase IGF-1 levels and reduce visceral fat. Tesamorelin is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Tesamorelin helps these individuals achieve normal growth and development.

-Pegvisomant (Somavert) is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Pegvisomant is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Pegvisomant helps these individuals achieve normal growth and development.

-Nampt (Ventavis) is a medication used to treat adults with growth hormone deficiency. It is a man-made form of growth hormone identical to the natural growth hormone produced by the body. Nampt is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. Nampt helps these individuals achieve normal growth and development.

-GHRP-6 is a peptide that is composed of amino acids. It is a GHRH analog, meaning it stimulates growth hormone release. GHRP-6 is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. GHRP-6 helps these individuals achieve normal growth and development.

-C-kit ligand is a peptide that is composed of amino acids. It is a GHRH analog, meaning it stimulates growth hormone release. C-kit ligand is available in an injectable form and is prescribed to adults unable to achieve normal growth and development with synthetic GH replacement therapy. C-kit ligand helps these individuals achieve normal growth and development.

What are the side effects of growth hormone therapy?

Side effects of GH therapy vary depending on the dose, frequency, and method of administration. Common side effects include:

-fluid retention

-joint pain

-carpal tunnel syndrome

-hypertension

-elevated blood sugar

-numbness and tingling in the hands and feet

-headaches

-mood changes

Rare side effects of GH therapy include: -diabetes mellitus -hypothyroidism -pituitary tumor -acromegaly (abnormal bone growth)

What is the outlook for people with growth hormone deficiency?

The outlook for people with GHD depends on the cause. If a pituitary tumor causes GHD, surgery can often cure the condition. If GHD is caused by head injury or surgery, GH replacement therapy can improve symptoms and quality of life. However, GHD cannot be cured. People with GHD will need lifelong GH replacement therapy.

Other Health New Articles:

Insulin Resistance and Weight Gain

Semaglutide Weight Loss

BOOK NOW

Call Today for an appointment!
678-443-4000